DUTCH Hormone Test

The Dried Urine Test for Comprehensive Hormones (DUTCH) is a functional laboratory panel that measures sex hormones, adrenal hormones, melatonin, organic acids, and their downstream metabolites through dried urine samples collected over a 24-hour period.

SeeBeyond Medicine uses the DUTCH test to reveal how your body produces, converts, and eliminates hormones. Standard blood draws capture a single moment in time. DUTCH testing maps the full metabolic pathway.

This evidence-based approach identifies estrogen dominance, cortisol dysregulation, and androgen imbalances with precision. SeeBeyond Medicine designs personalized protocols based on metabolite data, not guesswork.

What DUTCH Measures

The DUTCH panel analyzes three hormone categories in a single collection:

• Sex hormones: Estrogen and its key metabolites, progesterone, and androgens including testosterone and DHEA. Imbalances in these hormones drive menstrual irregularities, fertility challenges, PCOS, endometriosis, and mood instability.
• Adrenal hormones: Free and metabolized cortisol measured across four time points, plus DHEA-S. These markers reveal how your adrenal glands manage stress, regulate energy, and govern immune and inflammatory function.
• Melatonin and circadian markers: DUTCH measures melatonin output as a window into sleep and circadian rhythm disruption -- an often-overlooked driver of fatigue and downstream hormonal effects.

Metabolite Profiling and Steroid Hormone Pathways

What distinguishes DUTCH from other panels is metabolite profiling. Rather than measuring only how much estrogen circulates, DUTCH tracks where estrogen goes after it is produced. The three primary estrogen metabolites -- 2-hydroxyestrone, 4-hydroxyestrone, and 16-alpha-hydroxyestrone -- each carry different implications for breast tissue health and long-term cancer risk. SeeBeyond Medicine evaluates these pathway ratios and intervenes with targeted nutrients, methylation cofactors, and detoxification support to promote favorable estrogen clearance.

Steroid hormone pathways -- the enzymatic steps that convert one hormone into another -- are mapped in full. This identifies conversion bottlenecks such as excess aromatization of testosterone to estrogen, explaining symptoms that standard panels overlook entirely.

How DUTCH Differs from Blood and Saliva Testing

Blood tests measure circulating hormone levels at a single moment and cannot show what the body does with those hormones after they enter the tissues. Saliva testing improves on blood by capturing free hormone fractions but still misses downstream metabolite patterns. DUTCH combines the strengths of both while adding metabolite profiling that neither can provide. At SeeBeyond Medicine, DUTCH testing is preferred precisely because it answers the question patients deserve answered: not just how much hormone you have, but how your body processes it.

Who Benefits from DUTCH Testing

DUTCH testing is appropriate for anyone whose symptoms remain unexplained after standard workups. Common presentations at SeeBeyond Medicine's Scarsdale, NY office and Greenwich, CT office include persistent fatigue, weight resistance despite consistent effort, mood changes or anxiety, sleep disruption, PMS or irregular cycles, perimenopause and menopause symptoms, fertility challenges, and men experiencing low energy or reduced libido.

How Results Guide Your Protocol

When DUTCH results return, SeeBeyond Medicine physicians interpret every metabolite pattern against your full clinical picture. The report presents hormone levels graphically against reference ranges so patterns are immediately visible. This data directly informs decisions about bioidentical hormone replacement therapy, adaptogenic support for adrenal recovery, methylation cofactors to improve estrogen detoxification, and circadian interventions. Every recommendation is grounded in your specific biochemistry -- not a standard protocol applied to your age or gender alone.